安德鲁-加菲尔德AndrewGarfield....彼得-帕克/蜘蛛侠PeterParker/Spider-Man

艾玛-斯通EmmaStone....格温-斯坦西GwenStacy

杰米-福克斯JamieFoxx....电光人MaxDillon/Electro

戴恩-德哈恩DaneDeHaan....哈利-奥斯本（“小绿魔”）HarryOsborn

莎莉-菲尔德SallyField....AuntMay

马丁-辛MartinSheen....UncleBen

保罗-吉亚玛提PaulGiamatti....AlekseiSytsevich/TheRhino

菲丽希缇-琼斯FelicityJones

克里斯-库柏ChrisCooper....NormanOsborn

科鲁姆-费奥瑞ColmFeore

B-J-诺瓦克B.J.Novak

莎拉-加顿SarahGadon

斯坦-李StanLee....GraduationGuest

马尔顿-索克斯MartonCsokas....Dr.Kafka

克里斯-泽尔卡ChrisZylka....FlashThompson

丹尼斯-利瑞DenisLeary....CaptainStacy

卡丽-科尔曼KariColeman....HelenStacy

吉姆-甘特JimGunter....MikeStacy

RuthSundell....TimesSquareGirlfriend

RobTunstall....PanickedPedestrian

JohnLarkin....FriendofFamily

SalvatoreL.Rossi....Bully

菲利普-奥唐戈PhilipOdango....ChinatownResident

PatriciaHodges....ParkAvenuePedestrian

RobScebelo....RiotGuard(asRobertM.Scebelo)

DonAnstock....Student(uncredited)

ChristopherJamesCullen....NewsCameraman(uncredited)

AbigailFriend....GirlontheBoardwalk/Carousel(uncredited)

DennisMichaelGiammetta....PedestrianinTimesSquare(uncredited)

DarrylReubenHall....Stroller(uncredited)

NadirHasan....CarDriver(uncredited)

RenanKanbay....Pedestrian(uncredited)

ShanaKaplan....PedestrianinTimesSquare(uncredited)

PaulJudeLetersky....OscorpControlTowerTech(uncredited)

JoeLipari....Pedestrian(uncredited)

DanielT.Martin....BusinessmanPedestrian(uncredited)

D.J.Paris....ChinatownShopper(uncredited)

Ronke....Graduate\'sFriend(uncredited)

AlyssaRuland....GranddaughterinTimesSquare(uncredited)

ShadeRupe....ParkAvenueCheerer(uncredited)

OdetteWarder....Pedestrian(uncredited)